NAD is a Cellular Must!

Whether it is with your food choices, or adding regular daily exercise or indeed, adding NAD protandim. Upon latest reading, and finding some very “impressive” slides, I would really love to share that information with you. Also discovering that depressed or decreased NAD promotes adipogenesis, or fat cells production, is a huge “enforcement” for me: weight control is my life issue.

Personalized Nutrition

My dear readers! I would like to introduce you to the concept of personalized nutrition in accordance to your genetic profile. I am learning this from Dr. Jeffery Bland, MD, PhD and “father” of functional medicine and founder of Personalized Lifestyle Medicine Institute.
Hope you will enjoy his recent webinar. Please don’t hesitate to ask questions.
To everyone’s health.
Dr. Sveta Silverman, MD

Strange Posts!

We are very sorry about the recent posts, they were not made by us. We have fixed the issue and you will no longer be seeing strange posts. Please, stay tuned for new posts coming soon! Thank you for your ongoing support, we really appreciate it!

What is behind NRF1?

As you all know, I am a true advocate and totally “crazy” about NRF2 protein complex in health and disease. However, I keep learning more and more about “another” guy: NRF1. It turns out that properly up-regulated NRF1 is also critically important for our well-being.  We know that NRF1 is a protein complex, activating genes, responsible for mitochondrial biogenesis (production of new mitochondria).

NRF1 is a whole more than just our mitochondrial booster: 

  • “It is now widely recognized that NRF1 is a multifunctional protein with critical roles in diverse cellular functions…”
  • “NRF1 binds to ~691 genes encoding proteins regulating cellular growth, DNA replication, DNA repair, chromosome organization and mRNA processing. NRF1 binds to promoter sequences of thousands of genes involved in regulating RNA metabolism, DNA damage repair, protein translation, cell cycle progression and more…”
  • “NRF1 has also been found to regulate human telomere transcription..”
  • “NRF1 protects neural stem cells from neurotoxin-induced apoptosis and senescence-aka dementia”..

Bottom line: NRF1 protein complex needs and MUST be upregulated in a healthy manner.

Reference: Cellular Oncology, October 2018

REVIEW

Interplay between NRF1, E2F4 and MYC transcription factors regulating common target genes contributes to cancer development and progression
Kaumudi Bhawe & Deodutta Roy

https://link.springer.com/article/10.1007%2Fs13402-018-0395-3

The “Perfect” Superfood

As I was catching up on my emails emails and reading scientific conventional medical and alternative medicine journals, I was delighted to come across this paper:

Quantifying the effects of spirulina supplementation on plasma lipid and glucose concentrations, body weight, and blood pressure, published in November issue of: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Dovepress, This article is an incredible validation of my love, support and indeed,  my daily consumption of Spirulina.

Spirulina is a single-celled blue/green alga that thrives on sunshine and fresh water.

I quote Dr. J. Mercola, OD, an author of Fat for Fuel book, “Spirulina – In My Opinion, Nature’s Nearly ‘Perfect’ Whole Food”

The perfect source of protein

Spirulina is a source of perfect and complete protein, containing the array of all essential and amino acids.

It is rich in minerals, like magnesium, calcium, selenium and provides essential fatty acids, like gamma-linoleic acid to support heart and join health.  Spirulina is also rich in one of my favorite antioxidants: SOD (super oxide dismutase).

Spirulina helps to optimize our immune response, microgut. It helps with heavy metal detoxification and many more health benefits.

Spirulina’s deep green color is due to presence of phycocyanin, another very potent antioxidant.

A must-have superfood

So, in summary, I hope that your will consider including this amazing and beautiful superfood into your food armamentarium.

From my heart and from my table to yours,

Sveta


Here is an abstract of the above mentioned paper:

Purpose: Spirulina is generally used as a nutraceutical food supplement due to its nutrient profile, lack of toxicity, and therapeutic effects. Clinical trials have investigated the influence of spirulina on metabolic-related risk factors but have yielded conflicting results in humans. Here, we summarize the evidence of the effects of spirulina on serum lipid profile, glucose management, BP, and body weight by conducting a meta-analysis.

Materials and methods: Relevant studies were retrieved by systematic search of MEDLINE, EMBASE, Scopus databases, and reference lists of relevant original studies from inception to July 2018. Data were extracted following a standardized protocol. Two investigators independently extracted study characteristics, outcomes measures, and appraised methodological quality. Effect sizes were performed using a random-effects model, with weighted mean differences (WMDs) and 95% CIs between the means for the spirulina intervention and control arms. Subgroup analyses were conducted to explore the possible influences of study characteristics. Publication bias and sensitivity analysis were also performed.

Results: A total of 1,868 records were identified of which 12 trials with 14 arms were eligible. The amount of spirulina ranged from 1 to 19 g/d, and intervention durations ranged from 2 to 48 weeks. Overall, data synthesis showed that spirulina supplements significantly lowered total cholesterol (WMD = –36.60 mg/dL; 95% CI: −51.87 to –21.33; P=0.0001), low-density lipopro- tein cholesterol (WMD = –33.16 mg/dL; 95% CI: −50.52 to –15.75; P=0.0002), triglycerides (WMD = –39.20 mg/dL; 95% CI: −52.71 to –25.69; P=0.0001), very-low-density lipoprotein cholesterol (WMD = –8.02 mg/dL; 95% CI: −8.77 to –7.26; P=0.0001), fasting blood glucose (WMD = –5.01 mg/dL; 95% CI: −9.78 to –0.24; P=0.04), and DBP (WMD = –7.17 mmHg; 95% CI: −8.57 to –5.78; P=0.001). These findings remained stable in the sensitivity analysis, and no obvious publication bias was detected.

Conclusion: Our findings provide substantial evidence that spirulina supplementation has favorable effect on select cardiovascular and metabolic biomarkers in humans, including lipid, glucose, and DBP management.

Keywords: blood pressure, body weight, blood glucose, CVD, lipid, spirulina

 

My personal testimonial!

 

Please forgive me for not writing for so long. And it’s not that there is nothing to talk or share or teach, on contrary, there is plenty. My desire to share, teach, explain is stronger than ever.

As many of you know, I am a part of network marketing company.  I have been “sticking with it” for over five years. I hear many comments of skepticism and negativity about “that type of business”.

I would like to share my perspective with you. I am a double trained allopathic physician, Canadian Royal College of Physicians and Surgeons licensed doctor, and I have m in this “pyramid scam ” for half a decade.

I can’t help but wonder if I were to ask you – Do you think it is about money? Do you think it is a “hoax” and sensation?

I am pretty sure, you have an answer to those questions.

To be a conventional doctor who teaches alternative ways of health is an incredible responsibility. I would go as far to say it is “a bit of chutzpah, guts, and tears” with some fear as well. The responsibility of honesty, ethics and professional integrity, and the obligation of being on the verge of products medical science is incredible.

It is imperative that I stand by research for medical paper, not “testimonials” for validation. However,  I cannot hide the tears of joy and satisfaction of helping desperate people and see their stories and health improvements.

I am a skeptic, and as a result, I read, listen and learn every minute of my life.  Healthy skepticism is driving my desire to learn more, help more and to be opened to any health improving modality.

As a doctor, my passion is to understand the nature of chronic disease and cancer. If we do understand the nature of disease, we do have ways to “tackle it” and finally not only treat it, but actually cure it.

I sincerely want to see double blind placebo randomized control human studies, but there is no such thing in regulation guidelines for supplements research, so we do have to rely on blind peer-reviewed, properly conducted animal studies and studies on human cell lines.

I am so delighted to read case reports and retrospective reviews not only on our products, but other supplements and foods and herbs.

The reason I am in this business is because healthy life style with “essential” or “mandatory supplementation” is the present and future of health and medicine. My goal is to teach thousands about health.  My business partners do that with me and for me and of needy ones.  I have seen both our products and this business concept working continuously.

You and I just need to do it right, with love, kindness, honesty, highest ethical standards and integrity.

To health and love, I am changing the world to better:

Dr. Sveta Silverman, MD and proud networkmarketer.

The power of choice!

As I’m on the journey of becoming a better me; as a person, physician, health promoter, entrepreneur and leader; my dilemma is, “do I have to or do I choose to”?

When I say, “I have to”, it removes my inner commitment to the task, because the purpose of fulfilling the task becomes that it is “brought upon me”. At that point, I am just a passive follower.

When I say, “I choose to”, I am admitting responsibility to my own actions.

We always have a choice.

This mentality shifts my thinking to commitment of the true purpose of that task.

I still make a decision, whether I have to, or if I choose to; but I always have a choice.

It is my choice to work hard, and I love it.

It is my choice to teach health and I love it.

It is my choice to eat nutrient dense foods and I love it.

It is my choice to pray and meditate and love and I love it.

I choose to balance my life and not to sacrifice my family or marriage. I stand by my choice.

Let’s do this together

I choose to stay honest to myself. Will you join me in this quest?

I choose to love you,

sveta

Fatty fallacy!

Who wants to be fat? We all love and thrive to look better and slimmer, right?

Fats are a constant subject of dieting: low fats and high fats diets.  And what about that “dreadful” cholesterol, which is the precursor of the five major classes of steroid hormones: progestagens, glucocorticoids, mineralocorticoids, androgens, and estrogens and vit D3.

Fat is essential

We need our fats, all of it: saturated fats, mono and polyunsaturated fats. All of them play critically important roles in our metabolism.

It’s dreadful cold in Alberta, Canada, it’s showy winter and we need that insulation, that “fatty” heat to keep us warm.

There is evidence that: “… In contrast, replacement of Saturated Fatty Acids (SFA) with carbohydrates, particularly sugar, has been associated with no improvement or even a worsening of Cardio Vascular Disease (CVD) risk.  There is growing evidence that SFAs in the context of dairy foods, particularly fermented dairy products, have neutral or inverse associations with CVD..” (Annu Rev Nutr. 2015;35:517-43. doi: 10.1146/annurev-nutr-071714-034449).

Let’s talk about those famous omega fats: omega 3 and 6 and others: it is very important to watch for the ratio of omega 3 to omega 6 fatty acids, which should be 4:1 (omega 3-4 to omega 6-1). Of note: Canola Oil is very unbalances and mostly contains omega 6 short fatty acids.

The critical role of Omega on your health

Being a vegan, my food comes from plant sources, but in case of most health cellular benefits, animal derived omega 3 fats are better and here is why:

From Dr. J. Mercola, MD:

“..Omega-3 comes from both animal and plant sources. The primary animal sources are krill oil and fish oil. The primary plant sources are flaxseed, chia and hemp.

Marine animals such as fish and krill provide eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), which are mostly promoted for their protective effects on your heart. Flaxseed, chia, hemp, and a few other foods, on the other hand, offer alpha-linoleic acid (ALA).

You would want to choose an animal-based variety – most of the cellular health benefits linked to omega-3 fats are linked to the animal-based EPA and DHA, not the plant-based ALA.

Furthermore, ALA is converted into EPA and DHA in your body at a very low ratio. What this means is that even if you consume large amounts of ALA, your body can only convert a relatively small amount into EPA and DHA, and only when there are sufficient enzymes”…

Why “omegas” are so critically important for our health:

Back to  Dr. J. Mercola, MD:

“Omega-3 ranks among the most important essential nutrients out there today. In 2008, the American Journal of Clinical Nutrition2, 3, 4published three studies investigating the role of EPA and DHA omega-3 fatty acids in elderly populations.

Low concentrations of EPA and DHA resulted in an increased risk of death from all causes, as well as accelerated cognitive decline. The studies also suggest that a higher intake of omega-3s may bring certain health benefits that short-term supplementation cannot give.

Here is other evidence of omega-3 benefits:

1.Omega-3 benefits your heart health. An Italian study (GISSI)5 of 11,324 heart attack survivors found that patients supplementing with fish oils markedly reduced their risk of another heart attack, stroke, or death. In a separate study, 6 American medical researchers reported that men who consumed fish once or more every week had a 50 percent lower risk of dying from a sudden cardiac event than do men who eat fish less than once a month.

2.Omega-3 normalizes and regulates your cholesterol triglyceride levels. Compared to a statin, both fish oil and krill oil are more efficient in doing this. According to a study comparing the efficiency of krill and fish oils in reducing triglyceride levels,7 both oils notably reduced the enzyme activity that causes the liver to metabolize fat, but krill had a more pronounced effects, reducing liver triglycerides significantly more.

Fasting triglyceride levels are a powerful indication of your ability to have healthy lipid profiles, which can be indicative of your heart health.

Studies have also shown that omega-3 fats are anti-arrhythmic (preventing or counteracting cardiac arrhythmia), anti-thrombotic (prevents thrombosis or a blood clot within a blood vessel), anti-atherosclerotic (preventing fatty deposits and fibrosis of the inner layer of your arteries), and anti-inflammatory (counteracting inflammation – the heat, pain, swelling, etc).

  1. DHA affects your child’s learning and behavior.Do you want to maximize your child’s intellectual potential? A study published in Plos One in June 20138 linked low levels of DHA with poorer reading, and memory and behavioral problems in healthy school-age children. In another study published in the American Journal of Clinical Nutrition in August 2013,9 children who consumed an omega-3 fat supplement as infants scored higher on rule learning, vocabulary, and intelligent testing at ages 3 to 5.

Previous research also found that children with attention deficit hyperactivity disorder (ADHD) and related behavior or learning disabilities are more likely to have low omega-3 fat levels.

Optimize your brain health

Omega-3 has such great impact on your brain health – EPA and DHA keep the dopamine levels in your brain high, increase neuronal growth in the frontal cortex of your brain, and increase cerebral circulation.”

In conclusion:

Our lifestyle choices are so important: Happy days, happy fats, lots of laughs and hugs.

Say NO to angry sugar, say YES to happy fats.

On to health, love and life.

Sveta

 

 

A time to grow

Upon my return from the LifeVantage Global convention, I found new inspiration to write. Not about business, products, medicine, science, financial future and success, but about personal growth.

Personal growth

How do I become a better person and a better leader? John C. Maxwell, author of  “The 15 invaluable laws of growth,” answered this question by writing, “do the right things”! After reexamining “the laws of personal growth” in my own life, I feel empowered to do the right things. Like loving people… truly loving them: whole-heartedly helping others and being kind without the promise of reward or recognition.

To organize the day by building a system of “proper habituality.” To begin every morning in prayer, thankful for health and love, and to set aside a few minutes for personal development with reading, listening, and meditating.

To minimize “comfortable distractions” and increase productivity, creativity and accountability.

I love having a “daily mode of operations”, scheduling plans for the future, and setting weekly/monthly goals, but it’s hard to actually follow up.

Do the right things by being a leader who provides genuine, constant, and consistent support without micromanaging.

Do the right things by being a leader who listens, understands, and guides; not one who criticizes and patronizes.

Do the right things by believing in the right things, and acting from the heart.

Intentions are good, but words are cheap. Actions are so much better.

Bottom line:

  • I believe in myself and in the power of the “right things”,
  • I believe in the power of helping others without expecting reward or thanks.
  • I believe in the power of daily “habitual” personal development.
  • I believe in the greatness of every person.
I BELIEVE.