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What is behind NRF1?

As you all know, I am a true advocate and totally “crazy” about NRF2 protein complex in health and disease. However, I keep learning more and more about “another” guy: NRF1. It turns out that properly up-regulated NRF1 is also critically important for our well-being.  We know that NRF1 is a protein complex, activating genes, responsible for mitochondrial biogenesis (production of new mitochondria).

NRF1 is a whole more than just our mitochondrial booster: 

  • “It is now widely recognized that NRF1 is a multifunctional protein with critical roles in diverse cellular functions…”
  • “NRF1 binds to ~691 genes encoding proteins regulating cellular growth, DNA replication, DNA repair, chromosome organization and mRNA processing. NRF1 binds to promoter sequences of thousands of genes involved in regulating RNA metabolism, DNA damage repair, protein translation, cell cycle progression and more…”
  • “NRF1 has also been found to regulate human telomere transcription..”
  • “NRF1 protects neural stem cells from neurotoxin-induced apoptosis and senescence-aka dementia”..

Bottom line: NRF1 protein complex needs and MUST be upregulated in a healthy manner.

Reference: Cellular Oncology, October 2018

REVIEW

Interplay between NRF1, E2F4 and MYC transcription factors regulating common target genes contributes to cancer development and progression
Kaumudi Bhawe & Deodutta Roy

https://link.springer.com/article/10.1007%2Fs13402-018-0395-3

The “Perfect” Superfood

As I was catching up on my emails emails and reading scientific conventional medical and alternative medicine journals, I was delighted to come across this paper:

Quantifying the effects of spirulina supplementation on plasma lipid and glucose concentrations, body weight, and blood pressure, published in November issue of: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Dovepress, This article is an incredible validation of my love, support and indeed,  my daily consumption of Spirulina.

Spirulina is a single-celled blue/green alga that thrives on sunshine and fresh water.

I quote Dr. J. Mercola, OD, an author of Fat for Fuel book, “Spirulina – In My Opinion, Nature’s Nearly ‘Perfect’ Whole Food”

The perfect source of protein

Spirulina is a source of perfect and complete protein, containing the array of all essential and amino acids.

It is rich in minerals, like magnesium, calcium, selenium and provides essential fatty acids, like gamma-linoleic acid to support heart and join health.  Spirulina is also rich in one of my favorite antioxidants: SOD (super oxide dismutase).

Spirulina helps to optimize our immune response, microgut. It helps with heavy metal detoxification and many more health benefits.

Spirulina’s deep green color is due to presence of phycocyanin, another very potent antioxidant.

A must-have superfood

So, in summary, I hope that your will consider including this amazing and beautiful superfood into your food armamentarium.

From my heart and from my table to yours,

Sveta


Here is an abstract of the above mentioned paper:

Purpose: Spirulina is generally used as a nutraceutical food supplement due to its nutrient profile, lack of toxicity, and therapeutic effects. Clinical trials have investigated the influence of spirulina on metabolic-related risk factors but have yielded conflicting results in humans. Here, we summarize the evidence of the effects of spirulina on serum lipid profile, glucose management, BP, and body weight by conducting a meta-analysis.

Materials and methods: Relevant studies were retrieved by systematic search of MEDLINE, EMBASE, Scopus databases, and reference lists of relevant original studies from inception to July 2018. Data were extracted following a standardized protocol. Two investigators independently extracted study characteristics, outcomes measures, and appraised methodological quality. Effect sizes were performed using a random-effects model, with weighted mean differences (WMDs) and 95% CIs between the means for the spirulina intervention and control arms. Subgroup analyses were conducted to explore the possible influences of study characteristics. Publication bias and sensitivity analysis were also performed.

Results: A total of 1,868 records were identified of which 12 trials with 14 arms were eligible. The amount of spirulina ranged from 1 to 19 g/d, and intervention durations ranged from 2 to 48 weeks. Overall, data synthesis showed that spirulina supplements significantly lowered total cholesterol (WMD = –36.60 mg/dL; 95% CI: −51.87 to –21.33; P=0.0001), low-density lipopro- tein cholesterol (WMD = –33.16 mg/dL; 95% CI: −50.52 to –15.75; P=0.0002), triglycerides (WMD = –39.20 mg/dL; 95% CI: −52.71 to –25.69; P=0.0001), very-low-density lipoprotein cholesterol (WMD = –8.02 mg/dL; 95% CI: −8.77 to –7.26; P=0.0001), fasting blood glucose (WMD = –5.01 mg/dL; 95% CI: −9.78 to –0.24; P=0.04), and DBP (WMD = –7.17 mmHg; 95% CI: −8.57 to –5.78; P=0.001). These findings remained stable in the sensitivity analysis, and no obvious publication bias was detected.

Conclusion: Our findings provide substantial evidence that spirulina supplementation has favorable effect on select cardiovascular and metabolic biomarkers in humans, including lipid, glucose, and DBP management.

Keywords: blood pressure, body weight, blood glucose, CVD, lipid, spirulina

 

My personal testimonial!

 

Please forgive me for not writing for so long. And it’s not that there is nothing to talk or share or teach, on contrary, there is plenty. My desire to share, teach, explain is stronger than ever.

As many of you know, I am a part of network marketing company.  I have been “sticking with it” for over five years. I hear many comments of skepticism and negativity about “that type of business”.

I would like to share my perspective with you. I am a double trained allopathic physician, Canadian Royal College of Physicians and Surgeons licensed doctor, and I have m in this “pyramid scam ” for half a decade.

I can’t help but wonder if I were to ask you – Do you think it is about money? Do you think it is a “hoax” and sensation?

I am pretty sure, you have an answer to those questions.

To be a conventional doctor who teaches alternative ways of health is an incredible responsibility. I would go as far to say it is “a bit of chutzpah, guts, and tears” with some fear as well. The responsibility of honesty, ethics and professional integrity, and the obligation of being on the verge of products medical science is incredible.

It is imperative that I stand by research for medical paper, not “testimonials” for validation. However,  I cannot hide the tears of joy and satisfaction of helping desperate people and see their stories and health improvements.

I am a skeptic, and as a result, I read, listen and learn every minute of my life.  Healthy skepticism is driving my desire to learn more, help more and to be opened to any health improving modality.

As a doctor, my passion is to understand the nature of chronic disease and cancer. If we do understand the nature of disease, we do have ways to “tackle it” and finally not only treat it, but actually cure it.

I sincerely want to see double blind placebo randomized control human studies, but there is no such thing in regulation guidelines for supplements research, so we do have to rely on blind peer-reviewed, properly conducted animal studies and studies on human cell lines.

I am so delighted to read case reports and retrospective reviews not only on our products, but other supplements and foods and herbs.

The reason I am in this business is because healthy life style with “essential” or “mandatory supplementation” is the present and future of health and medicine. My goal is to teach thousands about health.  My business partners do that with me and for me and of needy ones.  I have seen both our products and this business concept working continuously.

You and I just need to do it right, with love, kindness, honesty, highest ethical standards and integrity.

To health and love, I am changing the world to better:

Dr. Sveta Silverman, MD and proud networkmarketer.

The power of choice!

As I’m on the journey of becoming a better me; as a person, physician, health promoter, entrepreneur and leader; my dilemma is, “do I have to or do I choose to”?

When I say, “I have to”, it removes my inner commitment to the task, because the purpose of fulfilling the task becomes that it is “brought upon me”. At that point, I am just a passive follower.

When I say, “I choose to”, I am admitting responsibility to my own actions.

We always have a choice.

This mentality shifts my thinking to commitment of the true purpose of that task.

I still make a decision, whether I have to, or if I choose to; but I always have a choice.

It is my choice to work hard, and I love it.

It is my choice to teach health and I love it.

It is my choice to eat nutrient dense foods and I love it.

It is my choice to pray and meditate and love and I love it.

I choose to balance my life and not to sacrifice my family or marriage. I stand by my choice.

Let’s do this together

I choose to stay honest to myself. Will you join me in this quest?

I choose to love you,

sveta

Fatty fallacy!

Who wants to be fat? We all love and thrive to look better and slimmer, right?

Fats are a constant subject of dieting: low fats and high fats diets.  And what about that “dreadful” cholesterol, which is the precursor of the five major classes of steroid hormones: progestagens, glucocorticoids, mineralocorticoids, androgens, and estrogens and vit D3.

Fat is essential

We need our fats, all of it: saturated fats, mono and polyunsaturated fats. All of them play critically important roles in our metabolism.

It’s dreadful cold in Alberta, Canada, it’s showy winter and we need that insulation, that “fatty” heat to keep us warm.

There is evidence that: “… In contrast, replacement of Saturated Fatty Acids (SFA) with carbohydrates, particularly sugar, has been associated with no improvement or even a worsening of Cardio Vascular Disease (CVD) risk.  There is growing evidence that SFAs in the context of dairy foods, particularly fermented dairy products, have neutral or inverse associations with CVD..” (Annu Rev Nutr. 2015;35:517-43. doi: 10.1146/annurev-nutr-071714-034449).

Let’s talk about those famous omega fats: omega 3 and 6 and others: it is very important to watch for the ratio of omega 3 to omega 6 fatty acids, which should be 4:1 (omega 3-4 to omega 6-1). Of note: Canola Oil is very unbalances and mostly contains omega 6 short fatty acids.

The critical role of Omega on your health

Being a vegan, my food comes from plant sources, but in case of most health cellular benefits, animal derived omega 3 fats are better and here is why:

From Dr. J. Mercola, MD:

“..Omega-3 comes from both animal and plant sources. The primary animal sources are krill oil and fish oil. The primary plant sources are flaxseed, chia and hemp.

Marine animals such as fish and krill provide eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), which are mostly promoted for their protective effects on your heart. Flaxseed, chia, hemp, and a few other foods, on the other hand, offer alpha-linoleic acid (ALA).

You would want to choose an animal-based variety – most of the cellular health benefits linked to omega-3 fats are linked to the animal-based EPA and DHA, not the plant-based ALA.

Furthermore, ALA is converted into EPA and DHA in your body at a very low ratio. What this means is that even if you consume large amounts of ALA, your body can only convert a relatively small amount into EPA and DHA, and only when there are sufficient enzymes”…

Why “omegas” are so critically important for our health:

Back to  Dr. J. Mercola, MD:

“Omega-3 ranks among the most important essential nutrients out there today. In 2008, the American Journal of Clinical Nutrition2, 3, 4published three studies investigating the role of EPA and DHA omega-3 fatty acids in elderly populations.

Low concentrations of EPA and DHA resulted in an increased risk of death from all causes, as well as accelerated cognitive decline. The studies also suggest that a higher intake of omega-3s may bring certain health benefits that short-term supplementation cannot give.

Here is other evidence of omega-3 benefits:

1.Omega-3 benefits your heart health. An Italian study (GISSI)5 of 11,324 heart attack survivors found that patients supplementing with fish oils markedly reduced their risk of another heart attack, stroke, or death. In a separate study, 6 American medical researchers reported that men who consumed fish once or more every week had a 50 percent lower risk of dying from a sudden cardiac event than do men who eat fish less than once a month.

2.Omega-3 normalizes and regulates your cholesterol triglyceride levels. Compared to a statin, both fish oil and krill oil are more efficient in doing this. According to a study comparing the efficiency of krill and fish oils in reducing triglyceride levels,7 both oils notably reduced the enzyme activity that causes the liver to metabolize fat, but krill had a more pronounced effects, reducing liver triglycerides significantly more.

Fasting triglyceride levels are a powerful indication of your ability to have healthy lipid profiles, which can be indicative of your heart health.

Studies have also shown that omega-3 fats are anti-arrhythmic (preventing or counteracting cardiac arrhythmia), anti-thrombotic (prevents thrombosis or a blood clot within a blood vessel), anti-atherosclerotic (preventing fatty deposits and fibrosis of the inner layer of your arteries), and anti-inflammatory (counteracting inflammation – the heat, pain, swelling, etc).

  1. DHA affects your child’s learning and behavior.Do you want to maximize your child’s intellectual potential? A study published in Plos One in June 20138 linked low levels of DHA with poorer reading, and memory and behavioral problems in healthy school-age children. In another study published in the American Journal of Clinical Nutrition in August 2013,9 children who consumed an omega-3 fat supplement as infants scored higher on rule learning, vocabulary, and intelligent testing at ages 3 to 5.

Previous research also found that children with attention deficit hyperactivity disorder (ADHD) and related behavior or learning disabilities are more likely to have low omega-3 fat levels.

Optimize your brain health

Omega-3 has such great impact on your brain health – EPA and DHA keep the dopamine levels in your brain high, increase neuronal growth in the frontal cortex of your brain, and increase cerebral circulation.”

In conclusion:

Our lifestyle choices are so important: Happy days, happy fats, lots of laughs and hugs.

Say NO to angry sugar, say YES to happy fats.

On to health, love and life.

Sveta

 

 

A time to grow

Upon my return from the LifeVantage Global convention, I found new inspiration to write. Not about business, products, medicine, science, financial future and success, but about personal growth.

Personal growth

How do I become a better person and a better leader? John C. Maxwell, author of  “The 15 invaluable laws of growth,” answered this question by writing, “do the right things”! After reexamining “the laws of personal growth” in my own life, I feel empowered to do the right things. Like loving people… truly loving them: whole-heartedly helping others and being kind without the promise of reward or recognition.

To organize the day by building a system of “proper habituality.” To begin every morning in prayer, thankful for health and love, and to set aside a few minutes for personal development with reading, listening, and meditating.

To minimize “comfortable distractions” and increase productivity, creativity and accountability.

I love having a “daily mode of operations”, scheduling plans for the future, and setting weekly/monthly goals, but it’s hard to actually follow up.

Do the right things by being a leader who provides genuine, constant, and consistent support without micromanaging.

Do the right things by being a leader who listens, understands, and guides; not one who criticizes and patronizes.

Do the right things by believing in the right things, and acting from the heart.

Intentions are good, but words are cheap. Actions are so much better.

Bottom line:

  • I believe in myself and in the power of the “right things”,
  • I believe in the power of helping others without expecting reward or thanks.
  • I believe in the power of daily “habitual” personal development.
  • I believe in the greatness of every person.
I BELIEVE.

A Doctor Who Markets an Avenue of Health

A doctor that makes a difference

I love being a doctor; but today’s blog is not about medicine, proper food or supplements. I had always wanted to follow my mother steps. She was a natural born healer, but going through my first medical school in Soviet Union, my heart wasn’t into it. It didn’t feel like my call. However, when I came to Canada, becoming a doctor indeed hit home for me: I love medicine through my microscope of cancer searching and being in the “club of surgical exclusivity”. I love the smell of operating room. I just love being a doctor and hope I make my mom proud and help people in their search for help, and even diagnosing breast cancer.

The power of belief

But I also love being a network marketer, which I began in 2013. It’s both the hardest and most rewarding profession. Proper network marketing is all about belief. If one believes in selling the “best soap ever”, it will be. It is a genuine power of belief in the products, science, company and people.

But why is it so hard to succeed?

Consistency, continuity and repetition

Network marketing is about consistency, continuity and repetition. It doesn’t matter how successful you are, every month starts with zeroes in the account and consistency, continuity and repetition again. That’s why one cannot succeed in this business without belief, and indeed, commitment. Honesty, integrity, professionalism and love for people don’t hurt either.  It’s a “grind with a passion, belief and love”!!!

What is there for me and why do I “stick” to this “pyramid scheme”?

As previously indicated, not only do I build my pyramid of love, but it certainly makes me a better, stronger, kinder and more committed person. So very often it is tempting and it would be so much easier to quit. Becoming a better person and a better leader is all about not quitting and searching for “easy”!

Leaving a legacy that opens an avenue of health

Network marketing is about helping yourself while helping others; and it is about building my legacy helping people to build their fortunes.  My legacy is about helping people make educated health choices and opening the avenue of health towards things people don’t know exists. This type of marketing happens through a word of mouth that makes people aware of their opportunity for health for life freedom.   This journey is about supporting people through thick and thin, while I give them my heart.

Robert Kyosaki, author, entrepreneur and motivator states:

“One of the beauties of network marketing is that it focuses on developing your emotional intelligence as well as your business skills”.

I send you all my love and wish for you all to try this amazing, hard, but soul searching,“becoming a better you,” business.

sveta

 

 

 

Merry Christmas and Happy Chanukkah!

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My amazing friends and followers!

I am so blessed, and thank to Karen Schenk, to connect with all of you on my blog.

From the bottom of my heart, I would love to wish you a very Merry Christmas and very Happy Chanukkah! Happy and healthy New year to all of you, your families, friends and everyone near and dear to you!

Please enjoy yourselves, family and friends!

This is a season of happiness, love and indeed resolutions to better us: health, wellness, everything.

Happy Holidays my friends, thank you for breathing me with oxygen of love, inspiration, hope, faith and gratitude.

Happy New Year,

sveta

 

Doctor, healer and levels of evidence

Let me start with thfullsizerender-jpge definitions of a doctor and a healer. A doctor is a qualified practitioner of medicine; a physician.  A healer is the one who restores to original purity or integrity.

As a doctor, I am always struggling with this question: am I a healer?

A mother delights in her children’s healing

I have met Hugh Lynn an amazingly beautiful young woman approximately 3 months ago. Hugh Lynn has three children: the oldest one, Mason was wheelchair bound at the time of meeting; he was born with cerebral palsy, the youngest, Austin, just over a year old toddler, was covered in the most severe eczema I have ever seen. I have revisited with Hugh Lynn and kids couple days ago and was img_1309broken into tears seeing Mason walking, and the youngest one, Austin, with almost cleared skin. Hugh Lynn bravely put her kids on NRF2 protandim 3 months ago. Mason speech therapist joined us into discussion with his feed back on Mason’s amazing cognitive improvement.

Well, there are no double blind placebo randomized control img_1311studies on protandim and cerebral palsy and should we “vehemently” oppose the supplements for the kids for the same reasons?

Not enough evidence, other MD’s would say.  I am not sure, whether Hugh Lynn needs to see the double blind placebo control studies now, because she is watching her sons improvement. Is there a greater joy for a mother to see her children get better and me, as a healer to see patient’s benefits?

I am also truly puzzled as to why a lot of allopathic physicians are “closed minded”, aka not open to alternative methods of medicine?

Let me get into the studies now.

Evidence based medicine

Is it due to conventional training methods, which are indeed drug oriented, or desire to practice “evidence based medicine”?

Let’s refer to definition of the Oxford (UK) CEBM Levels of Evidence, “Most of the evidence ranking schemes grade evidence for therapy and prevention, but not for diagnostic tests, prognostic markers, or harm. The Oxford CEBM Levels of Evidence addresses this issue and provides ‘Levels’ of evidence for claims about prognosis, diagnosis, treatment benefits, treatment harms, and screening.

The original CEBM Levels was first released in September 2000 for Evidence-Based On Call to make the process of finding evidence feasible and its results explicit. As published in 2009 they are:

1a: Systematic reviews (with homogeneity) of randomized controlled trials
1b: Individual randomized controlled trials (with narrow confidence interval)
1c: All or none randomized controlled trials
2a: Systematic reviews (with homogeneity) of cohort studies
2b: Individual cohort study or low quality randomized controlled trials (e.g. <80% follow-up)
2c: “Outcomes” Research; ecological studies
3a: Systematic review (with homogeneity) of case-control studies
3b: Individual case-control study
4: Case series (and poor quality cohort and case-control studies)
5: Expert opinion without explicit critical appraisal, or based on.”

As many of you aware, I am proud to be a LifeVantage distributor. LifeVantage is front-runner in Nutrigenomics (nutrigenomics is research focusing on identifying and understanding molecular-level interaction between nutrients and other dietary bioactives with the genome).

Randomized double blind placebo control human studies

Bringing these “pioneering” supplements, we are all faced with challenge to level of evidence to validity and health benefits.

The frequent question I am asked by physicians is: are there any double blind placebo randomized control human clinical trials?

Before I dive into the answer, here is the quote from Gugiu, PC; Westine, CD; Coryn, CL; Hobson, KA (3 April 2012). “An application of a new evidence grading system to research on the chronic care model”. Eval Health Prof. 36 (1): 3–43. doi:10.1177/0163278712436968. 2014.

“The limitations to the levels of evidence are:  the hierarchy of evidence produced by a study design has been questioned, because guidelines have “failed to properly define key terms, weight the merits of certain non-randomized controlled trials, and employ a comprehensive list of study design limitations”.

As a healer, my main purpose is to make a person feel better, whether it is less pain, more energy, better vitality or mobility.

What do I do if the supplement, vitamin, ingredient or remedy doesn’t have a double blind placebo randomized control human study validation?

Do I deny the person health benefit of the product?

“Longer lifespan in male mice treated with a weakly estrogenic agonist, an antioxidant, an a-glucosidase inhibitor or a Nrf2-inducer”, study conducted by The National Institute on Aging Interventions Testing Program (ITP) and published in the Aging Cell (2016) 15, pp872–884, is a milestone study, however many sceptics, including health care professionals, only see: it is a mice, not a human study.

A longer life

Well, for once, I would love to live longer and I would love to know what could I do to live longer and not to wait for human couple generations to follow up the conclusions study. Indeed, it will take few generations to conduct human study of this magnitude and I will not be around then. It’s a great idea and I do want my successors to benefit from longer life, but I want to live long and healthier too.

So, let’s get reasonable.

Research and testing results in a patient’s well being

In conclusion, indeed, as a licensed medical practitioner, I do need to practice evidence-based medicine, but as a licensed medical practitioner, I need to keep my “antennas” on every possible health advance, whether is it allopathic or naturopathic. I cannot harm neither my patients, not my friends or family with my medical recommendations. Indeed, before I suggest a natural product or take anything myself, I will do an extensive “read” around the topic with my source of information to be searched on www.pubmed.gov, but if I don’t see double blind randomized control human studies, I will search for every bit of evidence available on the NIH (National Institute of Health) digital database library website, consult the best expert in the area of interest, with my number one priority: the patient’s well being and health improvement.

Let’s thrive to health and longevity.

From my heart to yours,

Sincerely

sveta