NRF 1 – Mitochondria

My dear friends, I would love to introduce to you a little video about what is known to be “cellular engine”-mitochondria. 

Mitochondria is an intracellular organelle, looking like a little bacteria and it literally provides cells with energy and controls cellular health and our genes among other vital cellular processes.  

The number of mitochondria varies in different organs, for example: brain and skeletal muscles contain the largest numbers. 

It is proven that mitochondrial numbers and function declines with aging and indeed, contributes to chronic inflammation and disease. 

I hope that this brief video will encourage you to pay more attention to “those amazing little creatures” of life. 

To health and happiness we thrive. 


NRF2 Activation

My dearest friends and readers and followers! 

It is my deepest pleasure to introduce a second episode of my 5 parts mini-series on health and wellness. It is all about NRF2 activation. 

…”The Nrf2 signalling pathway is emerging as a critical and principal factor in the protection against cancer, neurodegeneration, and inflammation (Hayes and McMahon 2001; Droge and Schipper 2007; Nair et al.2007)…

Your health resides on cellular cleanliness and NRF2, cellular health guardian, is responsible for turning on “cellular vacuum cleaners” switch.

I would love to quote my NRF2 mentor and discoverer of NRF2-Keap1 regulatory complex Dr. M. Yamamoto, MD, PhD: 

…”Cellular detoxification is essential for health because it provides protection against various chemicals and xenobiotics. The KEAP1-NRF2system is important for cellular defense against oxidative and electrophilic stresses as NRF2 activates the transcription of an array of cytoprotective genes, including drug-metabolizing and antioxidant enzymes, in a stress-dependent manner…”

Please enjoy this presentation on health and I am so looking forward to your feedback, and questions. 

From my heart to yours, 

With love, Dr. Sveta Silverman, MD

Mini Series on Health

My dear friends, readers and followers! 

I am posting a series of 5 mini talks on health and lifestyle choices. 

The holidays are knocking on the door and during the festivities, we need to take care of our bodies and our souls. We are going to make those annual New Year resolutions to health, just to forget about them in a few days. 

No, health is our commitment and I believe an obligation not only to ourselves, but to our loved ones, especially children. 

I hope this mini series will serve as inspiration to further everyone’s personal commitment to health and happiness. 

The first video that I am going to share with you is about nutrient dense foods. I am going to share with you a quick and healthy lunch that I made in just a few minutes.

Happy holidays to you all. 

Dr. Sveta Silverman, MD 

We are Responsible for our Children’s Futures

My Dear Readers! 

When I was asked to talk about mental health, specifically autistic spectrum disorder and attention hyperactivity syndrome and oxidative stress, at the event to support “Smiles Non-profit shop society”, I was indeed uncomfortable: it is out of my zone of expertise. 

However, when there is a chance to educate health, I am “all on board”. 

I did my research of this issue and created a simple, very self-explanatory power point as to what can we improve for those afflicted by ADS and ADHD. 

Please take a moment and open this power point presentation to look through the “deck of slides”. It will be so amazing to see your feedback and thoughts. 

With love and gratitude, 

Sincerely your doctor of choice and “HUGS”,

Dr. Sveta Silverman MD. 

Are you Eating your Blueberries?

I am sure you know that I love to learn and teach, thus every morning starts with reviewing papers. And I love when medical/research papers enforce or validate or support and strengthen my knowledge.

Being a part of health and wellness company, it’s not that I promote my mitochondrial boosters or NRF2 activators, no,  I am on the path of discovering “all of them” and promoting “all of them”. Today’s paper on resveratrol  and curcumin, published in the November issue of Clinical Interventions in Aging is one of those validators.

I love to teach and spread the word of healthy living, so please eat your blueberries, and cook with turmeric.

And on top of it: it’s oxidative stress reducer, NAD and sirtuin boost, NRF2 activator and NFKB reducer-AWESOME.

..”In dark chocolate, resveratrol blends nicely with other antioxidants and also minerals, such as iron, copper and manganese. Blueberries don’t have quite as much resveratrol as grapes, but they are also a great source of other antioxidants, dietary fiber, vitamins C and K and manganese…”Please enjoy my latest Facebook post from one of my “morning update”: 

From Clinical Interventions in Aging, Nov 2019 issue:

Recovery Of Bone And Muscle Mass In Patients With Chronic Kidney Disease And Iron Overload On
Hemodialysis And Taking Combined Supplementation With Curcumin And Resveratrol:

..”Resveratrol can have several protective effects against age related disorders, including kidney diseases, through the activation of NAD dependent deacetylase and Sirtuin1. SIRT1 deacetylates several substrates and is an important regulator of a wide variety of cellular processes, including stress responses, cell survival, mitochondrial biogenesis and metabolism, occur in response to cellular energy levels and the redox state.

Regarding Turmeric, a study by Shain et al (2016) in Wistar rats treated with 100 mg/Kg/day and exercise for 6 weeks showed that Turmeric helps prevent muscle wasting by regulating NFKB and Nuclear factor erythroid (Nrf2). Furthermore, by deacetylating target proteins SIRT1
can regulate multiple cellular functions, including apoptosis, mitochondrial biogenesis, inflammation, glucose/lipid metabolism, autophagy and cellular stress adaptations. An excess of ROS plays a role in a variety of diseases, as well as in the aging process, which involves numerous cellular response pathways…”

With love,

Dr. Silverman

Photo by Joanna Kosinska on Unsplash

NAD is a Cellular Must!

Whether it is with your food choices, or adding regular daily exercise or indeed, adding NAD protandim. Upon latest reading, and finding some very “impressive” slides, I would really love to share that information with you. Also discovering that depressed or decreased NAD promotes adipogenesis, or fat cells production, is a huge “enforcement” for me: weight control is my life issue.

Personalized Nutrition

My dear readers! I would like to introduce you to the concept of personalized nutrition in accordance to your genetic profile. I am learning this from Dr. Jeffery Bland, MD, PhD and “father” of functional medicine and founder of Personalized Lifestyle Medicine Institute.
Hope you will enjoy his recent webinar. Please don’t hesitate to ask questions.
To everyone’s health.
Dr. Sveta Silverman, MD